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In the dynamic world of bioscience, understanding the precise molecular weight and aggregation behavior of biomolecules is crucial for drug development, protein engineering, and quality control. Agile Bioscience, a trailblazer in the field, has integrated the Waters Arc HPLC system with Wyatt's DAWN MALS and Optilab RI detectors (SEC-MALS) to achieve unparalleled precision in molecular weight determination and aggregate analysis. This case study delves into how Agile Bioscience leverages this powerful combination to accelerate their research and ensure the highest quality biotherapeutics.
Agile Bioscience's Challenges:
Accurate Molecular Weight Determination: Agile Bioscience needed a reliable method to determine the absolute molecular weight of their biomolecules, independent of retention time and column calibration.
Comprehensive Aggregate Analysis: Identifying and quantifying protein aggregates was critical for ensuring the safety and efficacy of their biotherapeutic products.
Streamlined Workflow: Agile Bioscience sought a solution that could seamlessly integrate SEC separation with advanced detection, minimizing manual intervention and maximizing efficiency.
The Arc HPLC & SEC-MALS Solution:
The combination of the Waters Arc HPLC system with Wyatt's DAWN MALS and Optilab RI detectors offered the ideal solution for Agile Bioscience's characterization needs. Here's how:
Precise Molecular Weight Determination: The DAWN MALS detector directly measures the absolute molecular weight of biomolecules, providing accurate results regardless of their size or shape. This eliminated the need for column calibration and ensured reliable data for Agile Bioscience's research.
Comprehensive Aggregate Analysis: The SEC-MALS setup allowed Agile Bioscience to detect and quantify protein aggregates with exceptional sensitivity. By combining size exclusion chromatography with multi-angle light scattering, they could differentiate between monomers, dimers, and higher-order aggregates.
Seamless Integration: The Waters Arc HPLC system seamlessly integrated with the Wyatt detectors, creating a streamlined workflow for Agile Bioscience's scientists. This reduced the time and effort required for analysis, allowing them to focus on interpreting results and making informed decisions.
Results & Impact:
The integration of SEC-MALS into Agile Bioscience's analytical toolkit has led to significant advancements:
Improved Accuracy: Agile Bioscience gained confidence in their molecular weight determinations, ensuring the quality and consistency of their biotherapeutics.
Enhanced Aggregate Profiling: The ability to precisely quantify protein aggregates allowed Agile Bioscience to optimize their purification processes and minimize the risk of immunogenicity in their products.
Accelerated Research: Streamlined workflows and automated data analysis saved valuable time and resources, enabling Agile Bioscience to accelerate their research and development timelines.
Agile Bioscience's Testimonial:
[Include a quote from a key scientist or manager at Agile Bioscience highlighting the benefits of using SEC-MALS with the Arc HPLC system.]
Conclusion:
Agile Bioscience's adoption of the Waters Arc HPLC system coupled with SEC-MALS demonstrates their commitment to cutting-edge analytical techniques. By harnessing the power of precise molecular weight determination and aggregate analysis, they have elevated their research capabilities and solidified their position as a leader in the bioscience industry.
Call to Action:
Empower your laboratory with the precision and efficiency of Waters Arc HPLC and SEC-MALS. Contact Waters today to explore how this powerful combination can transform your biomolecule characterization workflows.
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