Contact us

SV-AUC

Sedimentation Velocity Analytical Ultracentrifugation (SV-AUC) is a powerful technique for the in-depth characterization of protein aggregates and other biomolecular complexes. Agile BioScience leverages SV-AUC for orthogonal confirmation of aggregation, particularly for the assessment of soluble aggregates under 100nm.

Why SV-AUC Matters:

​

• Orthogonal Verification of Aggregates: Provides independent confirmation of aggregation levels detected with other techniques, strengthening your characterization data.

• Focus on Soluble Sub-100nm Aggregates: Delivers exceptional resolution for small aggregates, crucial for early detection and control of these potentially problematic species.

• Detailed Size Distribution: SV-AUC reveals the full distribution of aggregates, aiding in the understanding of aggregation pathways.

​

Our Approach:

​

• High-Performance Instrumentation: We utilize advanced analytical ultracentrifuges for precise determination of sedimentation coefficients.

• Expert Method Development: Our team carefully optimizes experimental conditions to ensure accurate and sensitive analysis of your biopharmaceutical.

• Data-Driven Guidance: We interpret SV-AUC data to provide actionable insights into aggregation levels and potential stability risks.

​

Benefits of Choosing Agile BioScience:

​

• Confidence in Aggregation Assessment: Gain a comprehensive understanding of aggregation in your product, especially the critical sub-100nm range.

• Problem-Solving Support: Identify the root causes of aggregation and optimize formulation conditions to minimize aggregate formation.

• Regulatory Readiness: Thoroughly characterize aggregates to support regulatory submissions and quality control.

​

Contact us to learn how SV-AUC can strengthen your biopharmaceutical development.