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Agile BioScience: Deciphering Protein Structure with Circular Dichroism
Circular Dichroism (CD)
Circular Dichroism (CD) spectroscopy is a sensitive technique for analyzing protein secondary and tertiary structure. Agile BioScience leverages CD to reveal crucial insights into your biopharmaceutical's conformation, stability, and potential changes.
Why CD Matters:
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Secondary Structure Analysis (Far-UV): CD detects characteristic patterns of alpha-helices, beta-sheets, and other structural elements, providing insights into protein folding and function.
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Tertiary Structure Analysis (Near-UV) reveal the distribution of amino acid residues with chromophoric side chains, including tryptophan, phenylalanine, tyrosine, and variations in the disulfide bond environment.
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Detects Subtle Changes: Highly sensitive to even minor structural alterations, aiding in the assessment of stability, manufacturing variations, and potential degradation pathways.
Our Approach:
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Far-UV and Near-UV Expertise: We perform CD analysis across the relevant spectral ranges for comprehensive structural characterization.
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Precise Instrumentation: Our CD spectrometers provide accurate, reproducible measurements.
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Expert Data Interpretation: Our team analyzes CD spectra to identify secondary and tertiary structure elements and pinpoint potential structural changes.
Benefits of Choosing Agile BioScience:
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In-Depth Structural Understanding: Gain detailed knowledge of your protein's conformation.
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Stability Assessment: Monitor structural integrity in response to environmental factors, formulation changes, or process modifications.
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Problem-Solving Support: Identify potential root causes of stability issues.
Contact us to discover how CD analysis can accelerate your biopharmaceutical development.
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